impact of biofilm on cefotaxime killing effect against Escherichia coli
نویسندگان
چکیده
Biofilms cause chronic infections that are difficult to treat because of the resistance microorganisms inside them. The goal is assess killing potential cefotaxime against Escherichia coli in biofilms obtained from clinical isolates kept microbiology laboratory Dr. Soetomo Surabaya Hospital. study was conducted by experimental design. Two steps challenged bacterial applying planktonic state and biofilm state. Minimum inhibitory concentration (MIC), minimum (MBIC), bactericidal (MBC) eradication (MBEC) were used as an indicator for comparison. Nineteen E this experiment, 7 with MIC 0.125-0.25 μg/ml (36,84%), 6 MBC value 0.25-0.5 (31,57%). MBIC > 128 (31,57%), MBEC 14 (73,68%). Cefotaxime had lower efficacy E. than phase. requires at minimal 5 times two-fold increase MIC, average 7-8 times. dilution MBC, 8 - 9 times.
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ژورنال
عنوان ژورنال: International Journal of Health Sciences (IJHS)
سال: 2022
ISSN: ['2550-6978', '2550-696X']
DOI: https://doi.org/10.53730/ijhs.v6ns4.12244